| abstract |
Compositions containing isolated exosomes derived from stem cells are provided for uses including treatment of joint disorders caused by infection, immunological disturbances, trauma and degenerative joint diseases such as, for example, rheumatoid arthritis, osteoarthritis, overuse and traumatic joint injury. The isolated exosomes contain increased levels of stress-response molecules, including heat shock molecules. Methods are provided that include administering, such as by injection, an effective amount of a composition containing isolated stem cell exosomes having increased levels of stress-response molecules to the joint of the subject. |