http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019135233-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18792c3223c9584fded21f05e7a9f91b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-785 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00 |
| filingDate | 2019-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e36db2a2e62e4f4dd7bf99fdbc8ea26 |
| publicationDate | 2019-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019135233-A1 |
| titleOfInvention | Process of preparing glatiramer acetate |
| abstract | Disclosed herein is a process of preparing a polypeptide copolymer by polymerizing a mixture comprising N-carboxyanhydrides of alanine, tyrosine, carboxylate-protected glutamate and an amine-protected lysine, to form a protected polypeptide copolymer, which is contacted with a bromine scavenger to form a mixture; subsequently contacting the mixture with a solution of hydrogen bromide in acetic acid, to deprotect carboxylate-protected glutamate; followed by deprotection of the amine-protected lysine. Further disclosed herein is process of deprotecting carboxylate-protected glutamate in a protected polypeptide copolymer described herein by contacting the protected polypeptide copolymer with a bromine scavenger, and subsequently with hydrogen bromide in acetic acid. Further disclosed herein are polypeptide copolymers preparable according to a process as described herein, pharmaceutical compositions comprising same, and methods utilizing same for treating a medical condition. |
| priorityDate | 2018-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 312.