http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019134620-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b1d8c2ae4d24f60d7ae2ef0af47360ea |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-53 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 |
| filingDate | 2018-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dc362772cb0a4de3d5450cc1415ce1a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_596d76d5ce07c6fc8c25004addb2653d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_147e0b175aa552c85ae869877c8c3f8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b58739b87b70f9329da108a68c19e1e2 |
| publicationDate | 2019-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019134620-A1 |
| titleOfInvention | Medical use of e3 ligase fbw7 in delaying aging and related diseases |
| abstract | Disclosed is a use of E3 ligase FBW7 in preparing a drug for delaying aging and for preventing and treating aging-related diseases by means of inhibiting telomere damage, wherein the amino acid sequence of the FBW7 is as shown in SEQ. No.2. Knockout or RNA interference inhibiting the gene expression of the FBW7, a gene mutant expressing the FBW7 competitively inhibiting the FBW7 protein, or the overexpression of TPP1 overcoming the degradation caused by the FBW7 can protect the chromosome telomere from damage caused by stress, such as radiation, bleomycin and hydrogen peroxide, prevent the degradation of TPP1 in the basic state or in the stress state, result in the effect of extending telomere length, increase the number of tissue stem cells, improve the pulmonary respiratory function in the basic state, and prevent the occurrence of lung tissue aging and pulmonary fibrosis in the stress state, and same can be used in preparing a drug for preventing and treating telomere dysfunction to provide ideas and means for anti-aging. |
| priorityDate | 2018-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 324.