| abstract |
A compound, the structural general formula of the compound being as shown in formula I: X-AB-Y (formula I); in formula I, X is any one selected from among -CO2H, -CONHZ, -CH=CH-CO2H, and -CH=CH-CONHZ, Z being any one selected from among a substituted or unsubstituted C1-C12 alkyl group and a substituted or unsubstituted aryl group and a hydroxyl group; Y=-NR1R2, wherein NR1R2 is a substituted or unsubstituted 3-membered to 9-membered nitrogen-containing heterocyclic hydrocarbon group; A and B are independently selected from a substituted or unsubstituted phenylene group and a substituted or unsubstituted azaphenylene group respectively. The compound or a corresponding pharmaceutical salt form thereof may simultaneously inhibit LSD1 and HDAC target proteins, thereby inhibiting the proliferation of multiple tumor cells, and having a good anti-tumor effect. |