http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019129815-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b81c3ecc9a3bd192c754216816991d8a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-80 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C225-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C249-02 |
| filingDate | 2018-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a98e6daa6a795afbf6800edd7425c892 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3aafd46df73e2b2083a5f4c36b3a799a |
| publicationDate | 2019-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019129815-A1 |
| titleOfInvention | Improvements in or relating to organic material |
| abstract | The invention provides a method for synthesizing a compound of formula (I) wherein each R independently represents an optionally substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy, acyl, carboxyl, hydroxyl, halogen, amino, nitro, cyano, sulfo or sulfhydryl group, in ortho, meta or para position to the cycloalkylamine moiety; R 1 and R 2 each independently represents a hydrogen atom, a lower alkyl group or a cycloalkyl group; R 3 represents a hydrogen group, substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy group; Y represents an oxygen atom, a sulfur atom, a NH group, a NR 4 group or a CH 2 group; R 4 represents a hydrogen atom or an alkyl, aryl or a heteroaryl group; and n and m each independently represents an integer from 1 to 5; or a pharmaceutically acceptable salt thereof; or a precursor thereof; wherein the method comprises one or more of the following steps: (a) reacting a compound of formula (II): (II) wherein R, R 3 , Y, n and m are as defined above in relation to the compound of formula (I) with an oxygenating agent, a first additive and a second additive in a solvent in a fluidic network or in a batch process under thermal and/or photochemical conditions to form a compound of formula (III): (III) wherein R, R 3 , Y, n and m are as defined above in relation to the compound of formula (I), (b) reacting a compound of formula (III) with a nitrogen containing nucleophile in the presence of a third additive and/or a solvent in the fluidic network or in a batch process under thermal conditions to form a compound of formula (IV): (IV) wherein R, R 1 , R 2 , R 3 , Y, n and m are as defined above in relation to the compound of formula (I); and/or (c) reacting a compound of formula (IV) in a fluidic network or in a batch process, optionally in the presence of a fourth 20 additive, under thermal conditions to form a compound of formula (I); wherein one or more of steps (a), (b) and/or (c) is carried out in a fluidic network that comprises micro- and/or meso-channels having an internal dimension of from 100 µm to 2000 µm. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11344510-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112299972-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114249794-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114249794-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11440879-B2 |
| priorityDate | 2017-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 120.