http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019127903-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14687eb1d34a9a00bd12725a2e42d611 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-60 |
| filingDate | 2018-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_128edcfb81fe388985361c06461b60b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c27279140df140e91fc364408a2d35f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_826988d5b02c219e0e722b5c12f4ca95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12d1810ab414288ce82be96cca89cbbc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c69b2f56b0e5e3143c5c0243c02c762d |
| publicationDate | 2019-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019127903-A1 |
| titleOfInvention | Simple preparation method for avibactam |
| abstract | Provided is a preparation method for Avibactam, comprising using piperidin-5-one-2S-formate II as a raw material, subjecting same to a condensation reaction with O-protective group hydroxylamine hydrochloride, then performing reduction, chiral separation and hydrolysis under alkaline conditions to obtain 5R-substitutent oxyaminopiperidine-2S-formic acid V; and then subjecting the compound to a cyclic urea forming reaction and a chloroformylation reaction with phosgene, triphosgene or diphosgene, and performing amidation, deprotection, sulphation, and tetrabutylammonium amminiation to form a salt {[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazacyclo[3.2.1]octane-6-yl]oxy}sulfonyltetra-n-butylammonium VII, and finally obtaining Avibactam I by means of ion exchange. The preparation method is simple, is easy to operate, has low raw material price, has low cost, has small amounts of "three wastes" emission, has high atomic utilization rate, is economical and environmentally friendly, and has high yield in each step, being beneficial to the industrial production of Avibactam. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115073458-A |
| priorityDate | 2017-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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