http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019124608-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_540ccaf9946fa77e2f12c36a44df226f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-10 |
| filingDate | 2017-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_147eba2421bb7d0d4e41c3eb2c4f0700 |
| publicationDate | 2019-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019124608-A1 |
| titleOfInvention | Pharmaceutical composition for preventing or treating rheumatoid arthritis, containing 4'-(p-toluenesulfonylamido)-4-hydroxychalcone as active ingredient |
| abstract | The present invention relates to a pharmaceutical composition for preventing or treating rheumatoid arthritis, containing 4'-(p-toluenesulfonylamido)-4-hydroxychalcone as an active ingredient. According to the present invention, in a K/BxN serum transfer arthritis model, 4'-(p-toluenesulfonylamido)-4-hydroxychalcone (TSAHC) can reduce ankle inflammation, bone erosion, cartilage damage and osteoclast activity and can reduce the expression of inflammatory cytokines, MMPs and RANKL. In addition, TSAHC can inhibit, in fibroblast-like synoviocytes of rheumatoid arthritis, TNF-α-induced cell proliferation and can inhibit the translocation and transcriptional activity of NF-κB. Therefore, the TSAHC of the present invention, having the above effects, can be effectively usable as a pharmaceutical composition for preventing or treating rheumatoid arthritis or a functional food composition for preventing or alleviating rheumatoid arthritis. |
| priorityDate | 2017-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 353.