http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019124607-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_540ccaf9946fa77e2f12c36a44df226f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-10 |
| filingDate | 2017-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c7d818e088135fafce7d6b3a6612c6a |
| publicationDate | 2019-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019124607-A1 |
| titleOfInvention | PHARMACEUTICAL COMPOSITION CONTAINING α-LIPOIC ACID, EVOGLIPTIN OR MIXTURE THEREOF AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING NON-ALCOHOLIC FATTY LIVER DISEASE |
| abstract | The present invention relates to a pharmaceutical composition containing α-lipoic acid, evogliptin or a mixture thereof as an active ingredient for preventing or treating non-alcoholic fatty liver disease. According to the present invention, α-lipoic acid, evogliptin, or a mixture thereof reduces expression of enzymes involved in synthesis of neutral fat and increases expression of enzymes involved in degradation of neutral fat in an animal model of non-alcoholic fatty liver disease induced by a high fat diet, thereby reducing fat accumulation in hepatocytes. Also, α-lipoic acid, evogliptin, or a mixture thereof can reduce cell death, oxidative stress, and vitamin D receptor expression, and inhibit expression of a protein associated with autophagy, thereby reducing autophagy. Accordingly, α-lipoic acid, evogliptin, or a mixture thereof of the present invention having the above-mentioned effects can be effectively used as a pharmaceutical composition for preventing or treating non-alcoholic fatty liver disease and a health food composition for preventing or treating non-alcoholic fatty liver disease. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022145512-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111983058-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111983058-B |
| priorityDate | 2017-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 215.