| abstract |
Benzimidazole derivatives of formula (I): (Formula (I)) wherein: R 1 is -(CH 2 ) m -R 7 , (Formula (II)) or (Formula (III)); R 2 is H, halo, -(CH 2 ) m -NH 2 , -(CH 2 ) n -C(=NH)-NH 2 or -(CH 2 ) n -NH-(CH 2 ) m -NHR 9 ; R 3 is H, F or Cl; each of R 4 , R 5 and R 6 is independently H or F; R 7 is C 1 -C 6 alkyl, CF 3 , -SO 2 R 11 , -NH-(CH 2 ) 2 -(NH) r -R 8 , -NH-CH(R 8 R 9 ) or a group of the following formula (A): (Formula (A)): W is -(CH 2 ) m -, -CH 2 -O-CH 2 -, -CH 2 -S-CH 2 -, -(CH 2 ) r -S(O) 2 -CH 2 -or -(CH 2 ) r -NR 8 -CH 2 -; m is an integer of 1 to 3; n is 1 or 2; p is 1 and V is CH; or p is 0 and V is N; q is 0 or 1; r is 0 or 1; R 8 is H, -SO 2 R 11 ,-SO 2 CF 3 , -COR 11 , -C(O)OR 11 , -CON(R 9 ) 2 or -(CH 2 ) n SO 2 R 11 ; R 9 is H or C 1 -C 6 alkyl, each R 9 being the same or different when two are present; R 10 is -SO 2 R 11 , -SO 2 CF 3 , -COR 11 , -CON(R 9 ) 2 or -(CH 2 ) n SO 2 R 11 ; and R 11 is C 1 -C 6 alkyl; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. |