Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a88b8ec09e31a28046ea82a2ee8b3e72 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y504-99039 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8243 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P5-007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y205-01021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-14001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y106-02004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0073 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01088 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82 |
filingDate |
2018-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f88f6d462446d738864724e535daf3b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e670e64e97f0fdadb45057e7dac55f6a |
publicationDate |
2019-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2019122259-A1 |
titleOfInvention |
Metabolic engineering |
abstract |
The invention relates generally to materials and methods for biosynthesising quillaic acid in a host by expressing heterologous nucleotide sequences in the host each of which encodes a polypeptide which in combination have said QA biosynthesis activity. Example polypeptides include (i) a Beta-amyrin synthase; (ii) an enzyme capable of oxidising Beta-amyrin or an oxidised derivative thereof at the C-28 position to a carboxylic acid; (iii) an enzyme capable of oxidising Beta-amyrin or an oxidised derivative thereof at the C-16α position to an alcohol; and (iv) an enzyme capable of oxidising Beta-amyrin or an oxidised derivative thereof at the C-23 position to an aldehyde. Preferred nucleotide sequences are obtained from, or derived from, Q. saponaria. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022136563-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3990651-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022136563-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023122801-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023180677-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022112523-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020260475-A1 |
priorityDate |
2017-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |