| abstract |
A method for activating and killing Kaposi's sarcoma herpesvirus (KSHV) includes (i) contacting latent KSHV with an amount of a compound according to Formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, effective to activate at least some of the latent KSHV, and (ii) contacting the activated KSHV with an amount of an α-hydroxytropolone effective to kill at least some of the activated KSHV. With respect to Formula I, R 1 is -N(R 2 )-C(0)-(CH 2 ) x -R 3 where R 2 is hydrogen or C 1 -C 3 alkyl, R 3 is a substituted amino group or a substituted or unsubstituted piperazinyl or piperidinyl group, and x is an integer from 0-10. |