| abstract |
The present invention relates to an oral pharmaceutical composition which contains the water-soluble, anti-cancer drug pemetrexed and a production method thereof, and more specifically, to an oral pharmaceutical composition wherein a complex is formed by the ionic coupling of a bile acid derivative which is an oral absorption enhancer with pemetrexed, the complex is included in a pharmaceutical additive and then pressed into capsule or tablet form, or is mixed with the internal aqueous phase of a water-in-oil-in-water (w/o/w) multi-emulsion nano-emulsion so as to improve the oral bioavailability of the water-soluble anti-cancer drug pemetrexed, thereby allowing production in an orally administrable form of pemetrexed, which is currently only administered in injection form, thereby ameliorating the inconvenience and problems with use of an injection, and can contribute to improving patient compliance and reducing medical costs. |