| abstract |
A combination prime:boost therapy is described herein. The combination therapy is for use in inducing an immune response in a mammal. The combination includes: an attenuated Listeria monocytogenes (LM) bacteria that is capable of expressing an antigenic protein, and that is formulated to generate an immunity to the protein in the mammal; and a boosting virus that is capable of expressing an antigenic protein, and that is formulated to induce the immune response in the mammal. The antigenic proteins are both based on the same tumour associated antigen, but need not be identical. An LM bacteria, methods of treatment, and uses are also described. |