| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d4dc8f7db08607c344fa0afbad4f8e3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-351
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-346
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2018-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab83b35a43cd34c8d3a96b97f4148a3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_282bcf8f94b38e53f7da899a094aa62c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95ec5c0dbea24599dac5e9838c830f5e |
| publicationDate |
2019-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019105419-A1 |
| titleOfInvention |
Nucleic acid, composition and conjugate containing same, preparation method, and use |
| abstract |
The present invention provides an siRNA for inhibiting apolipoprotein C3 (ApoC3) gene expression, and a pharmaceutical composition and conjugate containing the siRNA. Each nucleotide in the siRNA is a modified nucleotide. The siRNA contains a sense strand and an antisense strand; the sense strand contains a nucleotide sequence A, the nucleotide sequence A having a length that is equal to that of a nucleotide sequence represented by SEQ ID NO:1 and having no more than three nucleotide differences; the antisense strand contains a nucleotide sequence B, the nucleotide sequence B having a length that is equal to that a nucleotide sequence represented by SEQ ID NO:2 and having no more than three nucleotide differences. The siRNA and the pharmaceutical composition and conjugate thereof provided in the present invention can effectively treat and/or prevent dyslipidemia. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11660347-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023098908-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11492620-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021026150-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11633482-B2 |
| priorityDate |
2017-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |