| abstract |
Provided are a small interfering RNA (siRNA) that inhibits the expression of an angiopoietin-like protein 3 (ANGPTL3) gene, and a pharmaceutical composition and a conjugate comprising the siRNA; each nucleotide in the siRNA is independently a modified or unmodified nucleotide, and the siRNA comprises a sense strand and an antisense strand; the sense strand comprises a nucleotide sequence A, the nucleotide sequence A being equal in length to the nucleotide sequence as represented by SEQ ID NO: 1, having a difference of no more than 3 nucleotides; the antisense strand comprises a nucleotide sequence B, the nucleotide sequence B being equal in length to the nucleotide sequence as represented by SEQ ID NO: 2, having a difference of no more than 3 nucleotides. |