| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ffd5528fd07384d7b07ab484ed5b143 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-507
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2818 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30 |
| filingDate |
2018-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_208ae71db194c30eeeb84344554783c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32e778570e59a93680def9c24d238a35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b1352c55d3e593511669492d32c338d |
| publicationDate |
2019-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019094352-A1 |
| titleOfInvention |
Inhibition of ctla-4 and/or pd-1 for regulation of t cells |
| abstract |
Increases in CD4 + Foxp3 - PD-1 hi T cells (4PD1 hi ) in tumor-bearing hosts after CTLA-4 blockade show that these cells constitute an unconventional T-cell inhibitory subset with T FH - like features, which can affect the outcome of cancer immunotherapy. Evidence is provided that anti-PD-1/PD-Ll antibodies are a viable option to control these cells. Furthermore, treating cancer by administering immune checkpoint blockade therapy and monitoring circulating 4PD1 hi provides a more precise or personalized design of combination immunotherapies. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11643463-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022087230-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11013802-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11638755-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10912831-B1 |
| priorityDate |
2017-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |