| abstract |
The present invention relates to the field of research and clinical usage of extracellular vesicles. More in particular, the present invention relates to usages of recombinant extracellular vesicles comprising a) a self-assembling protein that directs its own release through vesicles as a luminal membrane bound protein and b) a heterologous marker. Indeed, the present invention provides recombinant extracellular vesicles which can be used as a biological reference material in methods to quantify extracellular vesicles in a sample, and/or, which can be used to calibrate a device for sample extracellular vesicles analysis, and/or, which can be used to evaluate the isolation process of extracellular vesicles. The present invention thus relates to improving the accuracy of an extracellular vesicle-based diagnosis. |