| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_64e1828ef896d7b7e7f7d1510ebe8e9f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_086f15631c977405b39139e88fe2224f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d5de9a1dac6b033c4643bb236ef4df3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
| filingDate |
2018-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3dd49ffe37159e85550cb04cc5b3dbc0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54b429165892351d7effbd8bc9a8807a |
| publicationDate |
2019-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019089623-A1 |
| titleOfInvention |
Fusion proteins for use in improving gene correction via homologous recombination |
| abstract |
Provided herein are fusion polypeptides each comprising a gene-editing nuclease enzyme such as CRISPR/Cas9 and a dominant-negative variant of p53 binding protein 1 (53BP1 DN variant). Such a fusion polypeptide can be used in gene editing to inhibit non- homologous end-joining (NHEJ) and enhancing homology-directed DNA repair. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3964574-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4004023-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022048823-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111455106-A |
| priorityDate |
2017-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |