| abstract |
The invention provides compositions comprising a biguanide derivative, such as chlorhexidine, for use in methods of preventing bacterial growth in a wound or surgical site of a subject. The methods involve irrigating or coating the wound or surgical site with the solution and then closing or covering the wound or surgical site without washing the solution of the wound or surgical site with saline or saline. 'water. The invention also relates to articles such as breast implants, tissue expander, titanium implants, tubes, surgical drains and devices designed to facilitate insertion or for sterile insertion of implants (e.g. Keller funnels) which are coated with a biguanide derivative. |