| abstract |
The present invention provides methods of inhibiting intra- and inter-cellular signaling pathways by modifying post-translational modification sites on selected target RNA molecules. In certain exemplary embodiments, the present invention relates to methods of inhibiting intracellular phosphorylation of serine, threonine, and tyrosine residues by editing the genetic codon of these amino acids using Site-directed RNA or RNA molecules. Embodiments of the present invention further relate to methods of inhibiting the pathological activation of cell signaling mediated by post-translational modifications, such as phosphorylation, which are involved in many diseases, including the cancer, immunodeficiency, infectious diseases, inflammatory disorders and neurodegenerative disorders. |