| abstract |
The present invention provides compositions and methods useful for the depletion of CD117 + cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers and autoimmune diseases, among others. In particular, the invention provides antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect treatment of these conditions, for example by depleting a population of CD117 + cells in a patient. , such as a human being. The compositions and methods described herein may be used to treat a disorder directly, for example, by depletion of a population of autoimmune cells or CD117 + cancer cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplantation therapy and to enhance the engraftment of hematopoietic stem cell grafts by selective depletion of endogenous hematopoietic stem cells prior to the transplantation procedure. . |