http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019081584-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15d317e32373a6d531ecf8a5650f95be |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6881 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6881 |
| filingDate | 2018-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1667dfd7dd2194d9bce53f40eb2b6f1a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8973dd801f9691009df6a36f1e899409 |
| publicationDate | 2019-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019081584-A1 |
| titleOfInvention | USE OF MCC AS AN EPIGENETIC MARKER FOR THE IDENTIFICATION OF IMMUNE CELLS, ESPECIALLY BASOPHILIC GRANULOCYTES |
| abstract | The present invention relates to a method, particularly an in vitro method, for identifying basophilic granulocytes, comprising analyzing a modification such as, for example, the methylation state of at least one CpG position in the mammal for the "colorectal cancer mutation" (MCC) gene, demethylation or lack of modification or methylation of said gene region indicating the presence of a basophilic granulocyte, as compared to a non-basophil granulocyte, or any other type of cell in peripheral blood or other tissues. The assays of the invention can identify basophilic granulocytes at the epigenetic level and distinguish them from all other cells, such as, for example, other blood or immune cells, in complex samples. The present invention further relates to an improved method for quantifying basophilic granulocytes, particularly in complex samples. The method can be carried out with or without a step of purifying and / or enriching the cells, preferably in whole blood and / or non-trypsinized tissue. Finally, the invention relates to primers, probes and amplicons based on bisulfite-treated nucleic acids. |
| priorityDate | 2017-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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