| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_015b06914223e1628bc6a0b3d09dcde5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_373a9b7fb8f054922fc382f5f189aad8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-329 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2018-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3a02c4103b470d62726fc9ac5f2b070
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d559c9336edcc9afd4039627b0454e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_630a5b375d551ddad888ee43516fed93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27220232c01a1e2be2884b7292f88aaf |
| publicationDate |
2019-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019081454-A1 |
| titleOfInvention |
METHODS AND COMPOSITIONS FOR PREDICTING AND TREATING INTRACRANIAL ANEURYSM |
| abstract |
The present invention relates to a method of predicting the risk that a subject develops or presents an intracranial aneurysm (IA) by identifying at least one mutation in an angiogenic protein, such as angiopoietin-like protein 6 (ANGPTL6). In particular, the inventors have identified a rare nonsense variant (c.1378A> T) in the last exon of the ANGPTL6 gene which encodes a circulating proangiogenic factor mainly secreted by the liver shared by the affected 4 affected members of a large genealogy. multi-carrier AI. The inventors have shown a 50% reduction in the serum concentration of ANGPTL6 in c.1378A> T heterozygous carriers compared to non-carrier parents, due to non-secretion of the truncated protein produced by the c1378A transcripts. T. They observed a higher rate of individuals with a history of high blood pressure among healthy carriers against carriers affected with ANGPTL6 variants, suggesting that ANGPTL6 could trigger cerebrovascular damage when combined with other risk factors such as hypertension. |
| priorityDate |
2017-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |