| abstract |
A chimeric antigen receptor, a modified NK cell thereof, a coding DNA, an mRNA, an expression vector, a preparation method, and an application are provided. The chimeric antigen receptor comprises an operably linked, sequentially tandem antigen binding domain, a spacer, a transmembrane domain, and an intracellular domain, the antigen binding domain being derived from a ligand binding region of NKG2D, The intracellular domain is derived from the intracellular signaling region of DAP12. |