| abstract |
The invention relates to isoquinoline compounds for the treatment of various diseases and conditions. The present invention relates more particularly to the use of an isoquinoline compound or analogs thereof in the treatment of disorders characterized by activation of Wnt pathway signaling (e.g. abnormal cell proliferation, angiogenesis, Alzheimer's disease, pneumonitis, inflammation, autoimmune diseases and osteoarthritis), modulation of cellular events mediated by Wnt pathway signaling, as well as states / disorders / neurological diseases associated with overexpression of DYRK1A. |