| abstract |
AM580 and structurally related compounds have been found to be useful in treating infection with a broad range of RNA and DNA viruses, and also in reducing an associated inflammation. This activity is independent of RAR-α signaling, and is not a result of activation of the innate immune response of the host. A broad antiviral activity of AM580 and structurally related compounds is modulation of lipogenesis to correct deregulation of this pathway in virus infected cells by inhibition of nSREPBP. |