| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b81a5eda0046acaa7b584105a93cd52 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-351
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2018-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab6ad7db148a00c25e4942f1984f9360
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d671c76746b17980da9e4aaf45df438
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1ab6f94fb73a6e14e0220571c465a71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dd855a98a294d85ce313b3bfdcb3712
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d27dbe4d959a7f95fe69b270fbd9b50 |
| publicationDate |
2019-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019079294-A1 |
| titleOfInvention |
RNAI-BASED AGENTS AND COMPOSITIONS FOR INHIBITING ASIALOGLYCOPROTEIN RECEPTOR 1 RECEPTOR 1 |
| abstract |
The present invention provides compositions and methods for inhibiting the expression of the Asialoglycoprotein Receptor 1 ( ASGR1 ) gene . Agents based on interference RNA (RNAi), p. ex. double-stranded RNAi agents, and ligand conjugates targeting an RNAi agent to inhibit the expression of an ASGR1 gene are described. The invention also relates to pharmaceutical compositions comprising one or more ASGR1 RNAi agents , optionally with one or more additional therapeutic agents. ASGR1 RNAi agents can be used in methods of treating various diseases and conditions, such as cardiometabolic diseases associated with high non-HDL (non-HDL-C) cholesterol levels, LDL cholesterol levels ( LDL-C), elevated total cholesterol levels and / or elevated triglyceride (TG) levels. |
| priorityDate |
2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |