| abstract |
The present invention relates to a novel combination therapy for reducing or preventing the acquisition of a conditioned response in a mammal comprising administering to the mammal a therapeutically effective amount of an aldehyde dehydrogenase inhibitor compound (ALDH-2), such as a compound of formula (I), in combination with a substance that produces the conditioned response, such as a drug containing a dopamine-producing agent such as an opioid, so that the combination acts to reduce or prevent the acquisition of a conditioned response, and the deleterious side effect of abuse, dependence, abuse and / or dependence. |