| abstract |
The invention relates to genetically modified regulatory T cells (Tregs), compositions thereof, and methods of use thereof. The Tregs provided by the present invention may be modified to include, for example, a chimeric antigen receptor (CAR), imparting increased stability, specificity, and immunosuppressive activity to a target antigen. In addition, the Tregs according to the present invention can also be modified to reduce the cytotoxicity functions of T lymphocytes. The invention also relates to methods of suppressing the immune response against a specific target antigen using modified Tregs according to the invention. 'invention. |