| abstract |
The present invention provides methods for genetic modification of microorganisms using advanced genome editing. Methods of modifying the genome of said microorganisms in terms of point mutations, deletions and DNA insertions are described. In addition, the inhibition of gene expression without manipulation of the genome of the microorganism is further described. In some cases, the microorganism may be a methylotrophic, e.g. eg, a methanotroph. |