| abstract |
The present invention relates to compositions comprising, in a liposome, bisantrene or a derivative or analog thereof, as well as compositions comprising, in a liposome, bisantrene or a derivative or analog thereof and an antimetabolite analogous thereto. pyrimidine such as cytarabine, as well as methods of using these compositions, particularly in the treatment of malignancies. The compositions enhance the stability and bioavailability of bisantrene or derivative or analog thereof and reduce the likelihood of occurrence and the severity of side effects, such as phlebitis and other circulatory system complications, administration of bisantrene or derivative or analog thereof and also provide an effective way of administering at least two antineoplastic agents, when the pyrimidine analog antimetabolite is included in the composition, in therapeutically effective amounts for treatment of a number of types of malignancies. |