http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019072889-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2511-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0018 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 |
| filingDate | 2018-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_454c98790acde9017ebc0d6d9a8b4bed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c7f91bde75ae7ec95b873a8a02857c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_668ecc7c836b11a5c6a9d96dc868a6bd |
| publicationDate | 2019-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019072889-A1 |
| titleOfInvention | MEDIUM OF INFUSION |
| abstract | The present invention relates to a method of culturing mammalian cells, for example, by cell perfusion culture, expressing a heterologous protein in a cell culture, comprising culturing mammalian cells expressing a heterologous protein in a culture medium comprising an amount of effective one or more lipid or lipid metabolites selected from the group consisting of: linoleic acid, arachidonic acid and prostaglandin E2 or derivatives and / or precursors thereof. Lipids or lipid metabolites or combinations thereof can lead to growth suppression and / or increased productivity with reduced cell purging. The present invention also relates to methods for increasing the productivity of a cell culture by culturing cells in a culture medium comprising an effective amount of one or more lipid or lipid metabolites selected from the group consisting of: linoleic acid, arachidonic acid and prostaglandin E2 or derivatives and / or precursors thereof. The present invention also relates to a culture medium for use in the production of therapeutic proteins with increased productivity, the medium comprising one or more lipids or lipid metabolites selected from the group consisting of: linoleic acid, arachidonic acid and prostaglandin E2 or derivatives and / or precursors thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11708572-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10975368-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10785574-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10704021-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11377651-B2 |
| priorityDate | 2017-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 649.