| abstract |
present invention relates to a process for obtaining nanostructured lipid carriers comprising buparvaquone coated with cationic and anionic polymers associated with a polypeptide by high pressure homogenization technology promoting the electrostatic interaction between its components in aqueous medium. Additionally, the present invention relates to the obtained nanostructured lipid carriers, which comprise from 0.5 to 50% w / v oil phase; 1 to 10% w / v surfactant; 50 to 500,000 IU / ml of a polypeptide; from 0.01 to 2% w / v of a cationic polymer; from 0.04 to 5% w / v of an anionic polymer; and purified water q.s.p. allowing, therefore, the site-specific release in macrophages, allowing the development of innovative drugs to advance the treatment of leishmaniasis. |