| abstract |
The present invention discloses a linker compound, a polyethylene glycol-linker conjugate, and derivatives thereof, and a polyethylene glycol-linker-drug conjugate. The linker compound and its combination with polyethylene glycol and its derivatives can be used for modifying drugs, and the modification reaction is simple, easy to carry out, the reaction yield is high, and the modified drug has a wide application range. The modified drug gradually degrades from the conjugate chain in the body, and can stay in the lesion (such as cancer) for a longer period of time, achieving the purpose of sustained release and controlled release, reducing the frequency of administration and greatly improving the bioavailability of the drug. And patient compliance. |