| abstract |
The invention discloses a degradation impurity N-formyl Paboxini in a solid preparation of Pabsini, a preparation method thereof, and the application thereof in the prescription research and impurity detection of the Parbsini solid preparation. Also provided is a stabilized paposini solid preparation and a process for the preparation thereof. The preparation method of N-formyl Paboxini can achieve product yield of more than 50% and purity of over 90%. It has simple process, high product purity, short production cycle, suitable for rapid laboratory preparation and large scale. Preparation and other advantages. The obtained Pabsini solid preparation was improved in stability, and the N-formyl Paboxini impurity was not increased in the Pabsini solid preparation after being left for 10 days at 60 ° C and 75% relative humidity. |