http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019056097-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db8acd71f5994544bda6df3f27a3f51e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D253-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0461 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2018-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4eea7c3e090b37a3b0614202be6eab8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38180bc9fe00471fb7a0f0a480cd241e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c109ea67a3d0668367386d03b487faf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a77ccb49ee40890b274f4d829cf812b2 |
| publicationDate | 2019-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019056097-A1 |
| titleOfInvention | MARKERS, CONJUGATES, COMPOSITIONS AND METHODS FOR IMAGING, CARTOGRAPHY AND THERAPY OF HYPOXIA |
| abstract | The present invention provides markers, conjugates, compositions and methods for imaging, mapping and hypoxia therapy. A compound comprising a bio-reductive activation arm (BA), a linker arm and a mapping click, BA containing one or more of the substituted or unsubstituted nitroimidazoles in 2/4/5 or benzotriazene-1,4 substituted dioxides or substituted 1,2,3 / 1,2,4-triazoles or substituted 1,4-benzoquinones or a combination of two homo-BA or hetero-BA fragments, the linker arm containing alkane, alkene linkers alkyne, alicyclic or aromatic C1-16 compounds, with or without heteroatoms as in ethers, amines, esters, acids, amides, 5- and 6-membered sugar rings with the substitution as described above , both monosaccharides and disaccharides, the mapping click containing one of -N3-, CN, SCN, substituted or unsubstituted, substituted alkynes for click chemistry. Said compound undergoes a click-in-situ reaction after its distribution into cells or tissues to bind to a reporter group that may be non-chelated or chelated by a radioactive or non-radioactive metal or a radiohalogen for PET / SPECT or a dye for a fluorescent / optical reporting group, thus performing hypoxia imaging. |
| priorityDate | 2017-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 141.