http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019055657-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D273-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D273-02 |
| filingDate | 2018-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b066d62780ee131bb2f15dd8c76741e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02fb1c9055aed520f961b6504b9f6e60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ebcd0831bcf22309fe36130b1406062 |
| publicationDate | 2019-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019055657-A1 |
| titleOfInvention | BAF COMPLEX MODULATION COMPOUNDS AND METHODS OF USE |
| abstract | The object of the present invention is to provide a new paradigm for the treatment of various pathological conditions in which the modulation of a BAF complex is sought. The invention relates to a strategy for modulating a BAF complex in a cell, and relates to effective compounds, pharmaceutical compositions, development strategies and treatment protocols, and also describes several advantages thereof. The invention relates to a novel family of BAF complex modulator compounds developed on the basis of a novel chemical scaffold comprising 12-membered macrolactam ring structures. Contacting target cells in vitro or in vivo with the compounds and compositions of the present invention can selectively inhibit the activity of BAF complexes in such cells. Certain BAF-modulating compounds in this family are particularly effective for the treatment of cancer in conjunction with an ATR inhibitor. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020264172-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020014524-A1 |
| priorityDate | 2017-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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