abstract |
The present invention relates to an anti-RAMP2 antibody having a cAMP inhibitory effect and an antiproliferative HUVEC effect. The present invention relates to an angiogenesis inhibitor containing said antibody as an active ingredient. In particular, the present invention relates, in an in vitro proliferation assay: an antibody against a receptor activity modification protein (RAMP2) having an anti-proliferative effect of vascular endothelial cells, or immunoreactive fragments thereof ; or an antibody having an effect of inhibiting the production of cAMP caused by animal cells by addition of adrenomedullin or immunoreactive fragments thereof. |