| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d0446a5bd77c7da68216fc2e3f05d48 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-22 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0678
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-39 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate |
2018-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc369b07bc5e887cea6fc1b67277b27d |
| publicationDate |
2019-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019053727-A1 |
| titleOfInvention |
REDIFFERENCING IN VITRO DEVELOPED CELLS FROM HUMAN PANCREATIC ISLAND BEA CELLS ADULPTED BY SMALL MOLECULE INHIBITORS OF THE SIGNALING PATH |
| abstract |
The present invention relates to a method for ex vivo increase of insulin content in pancreatic progenitor cells. The method comprises (a) contacting said pancreatic progenitor cells with a BRE mod amenity and extraterminal domain (BET) motif inhibitor and with an agent selected from the group consisting of an inhibitor of the NOTCH pathway, an inhibitor the TGF-beta pathway and an inhibitor of the WNT pathway under conditions that increase the insulin content in said pancreatic progenitor cells; and (b) analyzing the amount of insulin in, or secreted by, said pancreatic cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11612588-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11013752-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021029854-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023104015-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020237141-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10941118-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11566006-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11504354-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114317401-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4063487-A4 |
| priorityDate |
2017-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |