| abstract |
The present invention relates to the fields of medicine and cancer treatment. The invention relates more particularly to the use of a compound capable of decreasing or inhibiting, in vitro or ex vivo, the expression and / or the activity of MAFG and thus of increasing the production of ROS and the sensitivity to chemotherapy, specifically in cancer cells resistant to platinum therapy. The invention further relates to uses of such compounds, particularly for preparing a pharmaceutical composition for enabling or improving the efficacy of cancer treatment in a patient in need thereof. The compound of the invention may in fact advantageously be used, in combination with at least one chemotherapy drug, for the treatment of cancer, for the prevention of cancer metastasis and / or the prevention of cancer recurrence in a patient. The invention also relates to methods for preventing or treating cancer, cancer metastasis and / or cancer recurrence in a patient, as well as kits suitable for preparing a composition according to the present invention and or the implementation of the methods described in the description. |