| abstract |
The present invention relates to a fused heterocyclic benzene derivative of formula (I): --̅-̅-̅ represents a single or double bond; n is an integer which is 0 or 1; A represents -CH 2 -, -CH (OH) -, or - C (O) -; G is C or N; X is -CH 2 -, O, or -C (O) -; Y is an alkyl, aryl, or heterocyclic alkyl optionally substituted with at least one substituent independently selected from a group consisting of: H, halogen, alkyl, alkyl substituted by at least one halogen, aryl, aryl substituted with at least one halogen, - NR y1 R y2, -OR y1, y1 -R C (O) R y3, -C (O) R y1, -C (O) OR y2, -C (O) OR Ry3 y2 - y1 NR C (O ) R y2 , -NR y1 C (O) NR y2 R y3 , -NR y1 C (O) OR y2 R y3 , -NR y1 C (O) R y2 OR y3 , C (O) NR y1 (R y2 R) y3 ), -C (O) NR y1 (R y2 OR y1 ), -OR y2 R y3 , and -OR y2 OR y3 , each of R y1 and R y2 is independently selected from a group consisting of H, oxygen, alkyl and aryl, and R y3 represents an aryl optionally substituted with at least one halogen; Z represents -NR z1 R z2 , -NR z1 R z3 , -OR z1 , -OR z1 R z3 , -C (O) R z1 R z3 , -C (O) OR z1 R z3 , -NR z1 C (O) ) R R z2 z3, z1 -NR C (O) oR z2 z3 R, -C (O) NR z1 R z3, z2 oR or oR z3, each of R z1 and R z2 is independently selected from a group consisting of H , oxygen, alkyl and aryl, and R z3 represents an aryl optionally substituted with at least one substituent independently selected from the group consisting of: halogen, OH, -R za COOR zb , -OR za COOR zb , -R za SO 2 R zb , -R za SO 2 NR zb R zc R zd , -R za C (O) R zb R zc , -R za C (O) NR zb R zc R zd , -RZ a C (O) NR zb SO 2 R zc, Rza is nil or represents alkyl, R zb is H or alkyl, each of R zb and R zc is independently selected from a group consisting of H, OH, alkyl, aryl, alkoxyl, or NR zb R zc represents a nitrogen-containing heterocyclic alkyl ring, R zd is zero or represents an alkyl sulphonyl group. |