| abstract |
The present invention relates to pegylated amino acid compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3A , R 3B and n are as defined in the present invention. The present invention also relates to compositions which comprise a pegylated amino acid compound according to the invention, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, in association with a high concentration of a biological active ingredient (ABI) . In embodiments of the invention, ABI is an anti-PD-1 antibody or an antigen-binding fragment thereof that specifically binds to the programmed cell death receptor-1 (PD-1). ) human. The invention further relates to methods for lowering the viscosity of an aqueous solution of a pharmaceutical composition comprising adding a compound according to the invention to the solution. The invention also relates to methods of treating a disease or condition, such as cancer, by administering to a subject in need of such treatment a therapeutically effective amount of a composition. pharmaceutical composition according to the invention. |