| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e344e3af242781c989c8656851ef8006 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-54 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y401-01015
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-592
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-593
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-51 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-51 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-592
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-593
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-564
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate |
2018-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c80a7a58086bb1ebe11b2e5ce06094de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c81efa577a802f9411d079095c60a1f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10c2005e4e05fb7c405107f31032471e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8bbe55eda28e782ffdc3af486cef336
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2cb55e920ad437ecdacf427f1a32a8e |
| publicationDate |
2019-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019050458-A1 |
| titleOfInvention |
IMPROVED IMMUNOTHERAPY |
| abstract |
The present invention relates to a method for evaluating the efficacy of an immunotherapy comprising administering GAD to a patient, comprising the steps of: measuring the distribution of at least one of the subclass of IgG GADA; GADA rates; the distribution of cytokines secreted by lymphocytes; and proliferation of lymphocytes in the presence of GAD or CD3 / CD28 beads; in a first sample of blood, plasma or serum obtained from said patient at a first time and in a second sample of blood, plasma or serum obtained from said patient at a later time; and comparison of the measurements obtained as well. The invention further relates to novel dosing regimens of GAD in the treatment or prevention of type 1 diabetes, which may include administration by injection into a lymph node, oral administration of vitamin D and / or evaluation of the efficacy according to the above methodology followed by an adjustment of the dose and / or the route of administration on the basis of said evaluation. |
| priorityDate |
2017-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |