| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_13aca21b26cee456a069f562cf3988da |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 |
| filingDate |
2018-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21cc897b76e047276277ceba7aabf6ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd788dd69b430f789ae9392acca8b7c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81d5ee0a3ef5defe213c29a47001faa1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e896b4247cc1385d9e6a159257047e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c523c3ecc02fbd806768aac93055320
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc2cd20e8d80433424df26f9dc8044bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5161717febf63b9bddd809924f6a29f6 |
| publicationDate |
2019-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019049174-A1 |
| titleOfInvention |
SOLID STATE FORMS OF 5-CHLORO-6 - [(2-IMINOPYRROLIDIN-1-YL) METHYL] PYRIMIDINE-2,4- (1H, 3H) -DIONE HYDROCHLORIDE AND METHODS OF PREPARATION THEREOF |
| abstract |
The present invention relates to solid state forms of 5-chloro-6 - [(2-iminopyrrolidin-1-yl) methyl] pyrimidine-2,4- (1H, 3H) -dione hydrochloride of formula 1a and their methods of preparation and an improved process for the preparation of 5-chloro-6 - [(2-iminopyrrolidin-1-yl) methyl] pyrimidine-2,4- (1H, 3H) -dione hydrochloride. The present inventors also provide an amorphous polymorph of the combined drug consisting of 2'-deoxy-5- (trifluoromethyl) uridine and 5-chloro-6 - [(2-iminopyrrolidin-1-yl) methyl] pyrimidine-2,4-monohydrochloride. - (1H, 3H) -dione and its method of preparation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110054654-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112424211-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112424211-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11702439-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11465988-B2 |
| priorityDate |
2017-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |