| abstract |
The present invention relates to a polypeptide having the general amino acid sequence written as a single letter code Z 1 IX 2 RWX 5 X 6 KX 8 PX 10 X 11 SZ 3, X 2 = V, M or L, particularly L , X 5 = S or T, X 6 = K or R, in particular R, X 8 = V, M, L or F, in particular M, X 10 = Q or C, in particular C, X 11 = V, M or F, especially V; Z 1 = 0, Z 2 , or pyro glutamate, Z 2 = being a modification of the N-terminal nitrogen atom of the peptide chain, which modification forms together with the amino group of the N-terminal amino acid of peptide a moiety having the structure -NR 2 R 3 , R 2 and / or R 3 being independently of each other H or a substituted or unsubstituted acyl, alkyl, aryl, aralkyl, cycloalkyl and heterocycloalkyl group; Z 3 = 0, or Z 4 , Z 4 = being a modification of the C-terminal carboxyl group of the peptide chain, which modification together with the carboxyl group of the C-terminal amino acid of the peptide forms a fraction having the structure C (O) -OR 1 or -C (O) -NR 2 R 3 , R 1 being a substituted or unsubstituted alkyl, aryl, aralkyl, cycloalkyl and heterocycloalkyl group; and R 2 and R 3 are as defined above. |