| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37b36726b8c2d3a2fe627ab8caf1e052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03c4720e107878f494e6eb5a8e8500ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb414e28cd96b2b5ee298f2ae74b5fb2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-7095 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56972
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5047
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-564
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2018-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93cac3eeb5f11398fa868f48a61c03f9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa6f7f43cc9d44e6862d7191ede7a440
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcac3cbc506b1e212c536154a5742905
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91f2ae78ba14cf25035ba03be64caa51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59de2cabb7613ab4d2f0ff7a16fdf0a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_add32a70ca8d03e8a78e052798d5cd3d |
| publicationDate |
2019-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019048569-A1 |
| titleOfInvention |
METHODS AND KITS FOR DIAGNOSING FAMILY MEDITERRANEAN FEVER |
| abstract |
The present invention relates to a method for the non-invasive, specific and rapid diagnosis of Familial Mediterranean Fever (FMF) in a subject, said method comprising the step of measuring the level of cytokine (IL-18 or IL-1 beta) secreted by primary immune cells (or the cell death rate of these cells) obtained from said subject, which have been previously treated with a protein kinase C (PKC) inhibitor, and optionally previously treated with an NF-kB activator such as LPS. The inventors have demonstrated, on the basis of the in-depth study of the monocyte inflammasome process, that the PKC superfamily inhibitors trigger the activation of the inflammasome in the monocytes of FMF patients while they do not. do not have sufficient action for this in healthy donor monocytes (HD) or a patient with hyperimmunoglobulin D syndrome (HIDS). By means of quantitation or cytokine release determination of real-time cell death kinetics, the inventors demonstrate that PKC superfamily inhibitors can discriminate between patients with FMF HD or patients with systemic inflammation of other etiologies. . These results thus establish the basis for the development of a fast functional specific diagnostic test for FMF. The invention further relates to methods of treatment. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021247499-A1 |
| priorityDate |
2017-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |