| abstract |
Rho Kinase inhibiting compounds of formula (I) which are derivatives of tyrosine analogs, processes for their preparation, pharmaceutical compositions containing them and their therapeutic use. In particular, the compounds of the invention may be useful in the treatment of numerous disorders associated with enzymatic mechanisms of ROCK, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH). |