http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019047166-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c0f3dddfaf58ec1f83576f0ec60123a9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2810-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-635 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-01 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate | 2017-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f636cf4aecc9d2ae567f63ffdaae5d30 |
| publicationDate | 2019-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019047166-A1 |
| titleOfInvention | NUCLEIC ACID SYSTEMS THAT ALLOW BACTERIA TO SPECIFICALLY TARGET SOLID TUMORS THROUGH GLUCOSE DEPENDENT VIABILITY |
| abstract | A nucleic acid system introduced into a bacterial strain to generate a genetically modified bacterial strain that grows in solid tumors but does not grow in non-tumor tissues, the nucleic acid system comprising: a first a DNA fragment that encodes a toxin gene that expresses a toxin that kills the genetically modified bacterial strain; a second DNA fragment that encodes an antidote gene that expresses an antidote that cancels the toxin; a first promoter that controls the transcription of the antidote gene, so that the glucose represses the transcription of the antidote gene; and a first constitutive promoter that causes constitutive expression of the toxin gene; the second DNA fragment being transcribed in solid tumors but not transcribed in non-tumor tissues. |
| priorityDate | 2017-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.