abstract |
The present invention provides peptides comprising a monomeric Fc fragment of a neonatal receptor-recognized immunoglobulin (FcRn), a modified pre-fusion respiratory syncytial virus (RSV) protein F, and a trimerization domain. The invention further relates to nucleic acid sequences capable of encoding peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn), a pre-fusion respiratory syncytial virus (RSV) protein F modified, and a trimerization domain. The invention also relates to methods for eliciting a protective immune response against RSV, comprising administering to a subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by FcRn, a Prion F protein of pre-fusion modified, and a trimerization domain, the administration being performed on a mucosal epithelium. |