| abstract |
The present invention relates to solid state forms of roxadustat under the systematic name of (4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl) glycine of formula (I), their methods of preparation and use as a medicine. The solid form roxadustat forms of formula (I) according to the invention are prepared by reaction of the free acid of roxadustat with suitable co-formers (inorganic or organic acids, bases, neutral molecules, or salts or ion pairs) in a suitable solvent or solvent mixtures, the co-trainer is selected from the group consisting of meglumine, N, Ν'-dibenzylethylenediamine, tert-butylamine, diethylamine, dicyclohexylamine, ammonia, lithium, hydroxide, and the like. potassium, calcium salt, magnesium salt, iron (III) salt, iron (II) salt, 2-naphthalenesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, 3-ethyl-1-methyl-1H-imidazol acetate -3-ium and caffeine. |